About Syphilis, Symptoms, Diagnosis & Treatment

What is it?

Syphilis is a bacterial sexually transmitted infection (STI) that affects many organs / systems of the body. It is usually transmitted during unprotected vaginal, oral or anal sex. It can also be passed on from direct contact with your partner’sgenitals, even if there is no ejaculation. Infected mothers can pass syphilis to their unborn child or baby during labour and this can cause catastrophic consequences, therefore most pregnant women are offered a syphilis screening test early on in pregnancy.

How does it affect you?

Syphilis often does not cause any symptoms at all and is commonly only picked up from a blood test. If a person does develop symptoms these depend on the stage, as there are several stages of syphilitic infection. In between these stages the personremains symptom free.

Primary syphilis: a red lump or firm ulcer (chancre) appears at the site where syphilis enters your body (penis, vagina, or anus, or in the rectum, lips, or in the mouth) Because the sore is painless, it can easily go unnoticed. This chancre appearswithin three months of becoming infected, is highly infectious, and can be accompanied with swelling of local lymph glands. It resolves by itself, without treatment after 3 to 6 weeks.

Secondary syphilis commonly causes a general body rash, lymph gland swelling in the neck, groin or armpits, a flu like illness, fevers, patchy alopecia (hair loss), sore throat, headaches, weight loss, muscle aches, tiredness and mucous membranelesions (superficial sores in your mouth, vagina, or anus). The spotty rash is red, or reddish brown and usually appears on your trunk, the palms of your hands and/or soles of your feet. Less commonly you can develop a meningitis, hearing lossor eye involvement. These often appear within the first 6 months of infection.

The signs and symptoms of primary and secondary syphilis can be mild, and they might not be noticed. Without the right treatment, your infection will move to the latent and possibly tertiary stages of syphilis.

Latent stage is usually a period where the infected person has no symptoms or signs, often for many years. Most people with untreated syphilis do not develop tertiary syphilis.

Tertiary syphilis, if it develops, is the most serious stage of syphilis and can occur many years after infection (10-30 yrs). It can affect many different organ systems: heart and blood vessels, bones, skin, brain and nervous system (paralysis,dementia) and the results may be life threatening.


Syphilis can be identified from a simple blood test. In those with ulcers or mucous membrane lesions, a swab can be taken that can allow the organism to be seen under the microscope, there and then (allowing treatment to be given immediately),or a highly sensitive swab can be sent off to the laboratory. It can take up to three months after infection for a blood test to become positive so if you test within three months, and the test is negative, it is advisable to return again fora repeat test at a later date if you think you have been at risk.


If you test positive for syphilis we will ask you to attend a local sexual health clinic for treatment and follow-up. Treatment is fairly straightforward, and involves an injection of penicillin or a course of antibiotic tablets. The length oftreatment depends on the stage of infection.

Previous successful treatment for syphilis doesn't make you immune to catching the infection again but, some screening tests will always remain positive and you may have to undergo a different syphilis test to see if you have become re-infectedor if the initial infection has been inadequately treated. At SH.UK we may ask if you have had a history of syphilis before and one of our team will call you with your results if the screening test comes back as positive. At this point we will needto talk through with you when you last had syphilis, what treatment you received, what clinic this was given and what your last blood test results were. Depending on your answers you give, you may be referred to clinic for further investigationsor treatment, otherwise you will be reassured no further action needs be taken. It is always helpful for you to keep any treatment information about syphilis for future reference, to avoid being referred back to sexual health clinic unnecessarilyfor further tests or repeat treatment.

Contacting partners

If you are diagnosed with syphilis you will need to inform previous sexual partners as they may also be infected. How far back you go in contacting previous partners (look back period) depends on the stage of infection and your last negative syphilistest result (if you have ever had one). Your sexual health clinic doctor/nurse will advise you accordingly. Partners should be advised to attend a sexual health clinic for a syphilis test and may be offered treatment on the day they attend.If you feel unable to inform previous sexual partners one of our Health Advisers will be able to notify them on your behalf without revealing your identity.

You should have follow up syphilis blood tests to check that the infection has been treated appropriately.

Maintaining good sexual health and prevention

You should not have oral, anal or vaginal sex for a certain period of time after you have started treatment (your clinic will advise you accordingly) and until your current partner completes their treatment and until both youand your partner’s symptoms have abated. This is to avoid being re-infected and requiring further treatment.

If you have been infected with syphilis it is possible you may also have been infected with another STI. Therefore, it is advisable that you have a full sexual health screen for gonorrhoea, chlamydia, LGV, hepatitis B and C, and HIV. We adviseyou have another STI screen three months later because there is a higher risk of becoming infected with an STI (eg HIV) over the next year.

Use condoms as they help prevent transmission of syphilis by preventing contact with a sore. Be aware that infectious sores occur in areas not covered by a condom and transmission can therefore still take place. Encourage every partner to testfor STIs.

Additional Links